Jakob von Uexküll's theories of life -- Biography and historical background -- Nature's conformity with plan -- Umweltforschung -- Biosemiotics -- Concluding remarks -- Marking a path into the environments of animals -- The essential approach to the organism -- Heidegger and the biologists -- Paths to the world -- Disruptive behavior : Heidegger and the captivated animal -- The worldless stone -- The poor animal -- For example, three bees and a lark -- Animal morphology -- A shocking (...) wealth -- A fine line in the rupture of time -- An affected body -- The theme of the animal melody : Merleau-Ponty and the umwelt -- The structure of behavior -- A pure wake, a quiet force -- A leaf of being -- Interanimality -- The-animal-stalks-at-five-oclock : Deleuze's affection for Uexküll -- Problematic organisms -- Uexküll's ethology of affects -- The body without organs, the embryonic egg, and prebiotic soup -- Nature's refrain sung across milieus and territories -- The animal stalks. (shrink)

Emotion Review, Volume 14, Issue 3, Page 167-181, July 2022. A growing cadre of influential scholars has converged on a circumscribed definition of empathy as restricted only to feeling the same emotion that one perceives another is feeling. We argue that this restrictive isomorphic matching definition is deeply problematic because it deviates dramatically from traditional conceptualizations of empathy and unmoors the construct from generations of scientific research and clinical practice; insistence on an isomorphic form undercuts much of the functional value (...) of empathy from multiple perspectives of analysis; and combining the opposing concepts of isomorphic matching and self-other awareness implicitly requires motivational content, causing the RIM definition to implicitly require the kind of non-matching emotional content that it explicitly seeks to exclude. (shrink)

The U.S. Department of Health and Human Services has proposed substantial changes to the current regulatory system governing human subjects research in its Advanced Notice of Proposed Rulemaking, entitled “Human Subjects Research Protections: Enhancing Protections for Research Subjects and Reducing Burden, Delay, and Ambiguity for Investigators.” Some of the most significant proposed changes concern the use of biospecimens in research. Because research involving biological materials begins with an initial interaction with an individual, such research falls squarely within the human subjects (...) research regulatory framework known as the “Common Rule,” which applies to research conducted or funded by the HHS and the other signatory agencies and departments. However, as described in detail below, much biospecimen research may fall within exemptions and exceptions under the Common Rule and, thus, may be conducted without consent. The ANPRM proposes requiring written consent for research use of biospecimens, even if the biospecimens were initially collected for a purpose other than research or have been stripped of identifiers. (shrink)

This study considers customer characteristics as situational influences on a salesperson'sethical judgment formation. Specifically, customer gender, income, and propensity to buy were considered as factors which may bias these judgments. Additionally, the gender of the salesperson and their moral value structure were examined as moderating effects. An experiment using real estate agents reading hypothetical sales scenarios revealed differences across (1) customer gender, (2) customer income, and (3) level of the respondent'sidealism. Significant interactive effects with these factors were also found involving (...) respondent gender and level of idealism. These and previous findings which consider situational effects on ethical decision-making, indicate that a more contingent approach to ethics studies is warranted. (shrink)

The authors demonstrate that ethical judgments can be biased when previous judgments serve as a point of reference against which a current situation is judged. Scenarios describing ethical or unethical sales practices were used in an experiment to prime subjects who subsequently rated the ethics of an ethically ambiguous target scenario. The target tended to be rated as more ethical by subjects primed with unethical scenarios, and less ethical by subjects primed with ethical scenarios. This "contrast effect," however, is contingent (...) upon individual differences. Specifically, subjects with high (versus low) needs for cognition are more likely to process and use the information presented in the priming scenarios as a point of reference against which to judge the target situation, and hence more prone to the contrastive bias. Implications for avoiding unintentional moral relativism in business decision-making are discussed. (shrink)

The three commentaries on “Why We Should Reject the Restrictive Isomorphic Matching Definition of Empathy” mostly concurred with our critique of that widely adopted definition of empathy. Yet, commenters also raised important questions relating to the clarity and operationalizability of our recommended alternative: returning to a classical conceptualization of empathy as a dynamic, functionally oriented, multi-faceted unfolding process. To help contextualize these issues, we provide an extended analogy between empathy research and creativity research, areas of study which are conceptually linked (...) and have faced similar conceptual and methodological obstacles. In doing so, we highlight the challenge of distilling empathy down to a firm operationalizable definition without losing sight of the general meaning and real-world value of the construct. (shrink)

Emotion Review, Ahead of Print. The three commentaries on “Why We Should Reject the Restrictive Isomorphic Matching Definition of Empathy” mostly concurred with our critique of that widely adopted definition of empathy. Yet, commenters also raised important questions relating to the clarity and operationalizability of our recommended alternative: returning to a classical conceptualization of empathy as a dynamic, functionally oriented, multi-faceted unfolding process. To help contextualize these issues, we provide an extended analogy between empathy research and creativity research, areas of (...) study which are conceptually linked and have faced similar conceptual and methodological obstacles. In doing so, we highlight the challenge of distilling empathy down to a firm operationalizable definition without losing sight of the general meaning and real-world value of the construct. (shrink)

The second edition of the Critique of Pure Reason contains several major and myriad minor emendations. The revision of the mode of presentation is apparent in four sections of the Critique: the Aesthetic; the Doctrine of the Concepts of the Understanding; the Principles of Pure Understanding; and ‘the paralogisms advanced against rational psychology’ . A new refutation of psychological idealism begins at B274. Perhaps most importantly, a new Preface frames the Critique.

The method of the philosophers of the future that Nietzsche heralds, but does not self-identify with, has not received the attention it deserves in the secondary literature. In this essay, I address this lacuna with an interpretation of the roles of the philosophers of the future that explains in what sense they are and are not (at)tempters. As free spirits, cultural physicians, and legislators, the philosophers of the future undertake experiments to acquire knowledge; hence, the philosophers of the future are (...) attempters. Nevertheless, it is also wrong to call them attempters; as educators, the philosophers of the future are tempters. (shrink)

Transient receptor potential vanilloid 4 (TRPV4), a member of the TRP superfamily, is a broadly expressed, cell surface‐localized cation channel that is activated by a variety of environmental stimuli. Importantly, TRPV4 has been increasingly implicated in the regulation of cellular morphology. Here we propose that TRPV4 and the cytoskeletal remodeling small GTPase RhoA together constitute an environmentally sensitive signaling complex that contributes to pathological cell cytoskeletal alterations during neurological injury and disease. Supporting this hypothesis is our recent work demonstrating direct (...) physical and bidirectional functional interactions of TRPV4 with RhoA, which can lead to activation of RhoA and reorganization of the actin cytoskeleton. Furthermore, a confluence of evidence implicates TRPV4 and/or RhoA in pathological responses triggered by a range of acute neurological insults ranging from stroke to traumatic injury. While initiated by a variety of insults, TRPV4–RhoA signaling may represent a common pathway that disrupts axonal regeneration and blood–brain barrier integrity. These insights also suggest that TRPV4 inhibition may represent a safe, feasible, and precise therapeutic strategy for limiting pathological TRPV4–RhoA activation in a range of neurological diseases. (shrink)

This book provides a reconstructive and critical interpretation of Sartre’s mature dialectical ethics. Taken together, as Sartre intended, the posthumously published key texts demonstrate that the ultimate goal of praxis is “integral humanity” and that “making the human” is always possible because the means to humanity can always be invented.

Ecological crisis is being widely discussed in society today and therefore, the subject of religious naturalism has emerged as a major topic in religion. The Routledge Handbook of Religious Naturalism is an outstanding reference source to the key topics, problems, and debates in this exciting subject and is the first collection of its kind. Comprising thirty-four chapters by a team of international contributors, the Handbook is divided into seven parts: ¿ Varieties of religious naturalism and its relations to other outlooks (...) ¿ Some earlier religious naturalists ¿ Pantheism, materialism, and the value-ladenness of nature ¿ Ecology, humans, and politics in naturalistic perspective ¿ Religious naturalism and traditional religions ¿ Putting religious naturalism into practice ¿ Critical discussions of religious naturalism. Within these sections central issues, debates, and problems are examined, including: defining religious naturalism; religious underpinnings of ecology; natural piety; the religious-aesthetic; ecstatic naturalism as deep pantheism; spiritual ecology; African-American religious naturalism; Christian religious naturalism; Dao and water; Confucianism; environmental action; and practices in religious naturalism. The Routledge Handbook of Religious Naturalism is essential reading for students and researchers in religious studies, theology, and philosophy. The Handbook will also be useful for those in related fields, such as environmental ethics and ecology. (shrink)

Answering important public health questions often requires collection of sensitive information about individuals. For example, our understanding of how HIV is transmitted and how to prevent it only came about with people's willingness to share information about their sexual and drug-using behaviors. Given the scientific need for sensitive, personal information, researchers have a corresponding ethical and legal obligation to maintain the confidentiality of data they collect and typically promise in consent forms to restrict access to it and not to publish (...) identifying data.The interests of others, however, can threaten researchers' promises of confidentiality when legal demands are made to access research data. In some cases, the subject of the litigation is tightly connected to the research questions, and litigants' interest in the data is not surprising. Researchers conducting studies on tobacco or occupational or other chemical exposures, for example, are relatively frequent targets of subpoenas. (shrink)

In Testing for Athlete Citizenship: Regulating Doping and Sex in Sport, Kathryn E. Henne provides ‘a genealogical account of anti-doping regulation by questioning the meanings we take from sport’ (...

Under resource dependence theory, firms should benefit from diverse boards of directors. Ethical arguments also highlight that boards should be as diverse as the stakeholders and communities that they serve. In an attempt to increase diversity and women’s presence on boards of directors, legislative efforts have enacted gender quotas. We examine how such efforts are perceived by U.S. market participants. We expect that when a firm operating under a quota law meets only the minimum requirement, investors will view the female (...) directors through the lens of token status theory and invest fewer resources in that firm than they will in a firm that exceeds the quota minimum or has the same composition but is not under a quota law. Through an experiment with 207 MTurk participants, we manipulated whether a firm was or was not under a quota law and whether the number of female board members was just at or exceeded the law’s minimum compliance. We find evidence that under a quota system, U.S. market participants tend to view female directors as tokens when the firm is just at the quota minimum, and these perceptions both affect their view of the firm’s prospects and negatively influence investment decisions. Importantly, however, we find that these negative effects can be offset and that resource dependence theory holds if the firm _exceeds_ the quota, signaling that the hiring of female directors is not simply compliance-dependent and subsequently leading U.S. market participants to invest more resources in the firm. (shrink)

Hastings Center Report, Volume 52, Issue S1, Page S83-S88, March‐April 2022.

BackgroundRandomized controlled trials (RCTs) are often complex and expensive to perform. Less than one third achieve planned recruitment targets, follow-up can be labor-intensive, and many have limited real-world generalizability. Designs for RCTs conducted using cohorts and routinely collected health data, including registries, electronic health records, and administrative databases, have been proposed to address these challenges and are being rapidly adopted. These designs, however, are relatively recent innovations, and published RCT reports often do not describe important aspects of their methodology in (...) a standardized way. Our objective is to extend the Consolidated Standards of Reporting Trials (CONSORT) statement with a consensus-driven reporting guideline for RCTs using cohorts and routinely collected health data.MethodsThe development of this CONSORT extension will consist of five phases. Phase 1 (completed) consisted of the project launch, including fundraising, the establishment of a research team, and development of a conceptual framework. In phase 2, a systematic review will be performed to identify publications (1) that describe methods or reporting considerations for RCTs conducted using cohorts and routinely collected health data or (2) that are protocols or report results from such RCTs. An initial “long list” of possible modifications to CONSORT checklist items and possible new items for the reporting guideline will be generated based on the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) and The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) statements. Additional possible modifications and new items will be identified based on the results of the systematic review. Phase 3 will consist of a three-round Delphi exercise with methods and content experts to evaluate the “long list” and generate a “short list” of key items. In phase 4, these items will serve as the basis for an in-person consensus meeting to finalize a core set of items to be included in the reporting guideline and checklist. Phase 5 will involve drafting the checklist and elaboration-explanation documents, and dissemination and implementation of the guideline.DiscussionDevelopment of this CONSORT extension will contribute to more transparent reporting of RCTs conducted using cohorts and routinely collected health data. (shrink)

Is a Christian naturalism possible? It sounds like a contradiction in terms. However, depending on the meaning of the terms, it is not only possible but highly desirable. The purpose of this article is to sketch the possibility of a Christian naturalism, drawing on a number of twentieth- and twenty-first-century theologians. Naturalism is a contrast term, like “left” or “up,” which gets its meaning partly from opposition to another term, in this case “supernaturalism” or sometimes “supranaturalism.” It is a set (...) of beliefs which focuses on this world. (Of course, there is no other world, according to naturalism, but since Christians and others have often spoken of God, soul, and/or heaven as distinct from .. (shrink)

Thomas Kuhn has argued that scientists never reject a paradigm without simultaneously accepting a new paradigm. Coupled with Kuhn's claim that it is paradigms as a whole, and not individual theories, that are accepted or rejected, this thesis is seen as one of Kuhn's main challenges to the rationality of science. I argue that Kuhn is mistaken in this claim; at least in some instances, science rejects a paradigm despite the absence of a successor. In particular, such a description best (...) fits Kuhn's most discussed example, the Copernican Revolution. By differentiating scientific discoveries into three types, spontaneous, implicit, and directed, we see that Kuhn's thesis holds for spontaneous and implicit discoveries, but not directed discoveries. Directed discoveries must be understood by an alternative account of falsifiability, based on argument by reductio ad absurdum rather than argument by modus tollens as traditional accounts of falsifiability would have it. (shrink)

This article opens with two generic definitions of religious naturalism in general: one by Jerome Stone and one by Rem Edwards used by Charley Hardwick. Two boundary issues, humanism and process theology, are discussed. A brief sketch of my own “minimalist” and pluralist version of religious naturalism follows. Finally, several issues that are, or should be, faced by religious naturalists are explored.

Actin plays several essential roles in cellular processes and is a vital component in the contractile apparatus. To accomplish its many cellular tasks, actin must interact with a wide range of other proteins in addition to self‐assembling into filaments. Characterization of these functional domains and localized binding regions on the actin monomer is therefore an important undertaking. Strategies for elucidating the many interaction sites include X‐ray diffraction, NMR and fluorescence spectroscopy, chemical modification, chemical cross‐linking, protein cleavage, and the study of (...) sequence homologies between the many isotypes of actin. Based on these varied data, we discuss the possible spatial relationships between the interaction sites. (shrink)

Near the beginning of In Toga Candida, Cicero informed his audience of a private meeting between his two most serious competitors for the consulate and the managers of their campaigning funds. This meeting took place at the house of a nobleman whom Cicero did not name but to whom he attributed a signal notoriety in the practice of electoral corruption. Asconius offers a solution without hesitation: it was at the house of either Caesar or Crassus. He explains his choice: these (...) two men were Cicero's most committed and influential opponents in his campaign for the consulate, and he has excellent evidence for their opposition: Cicero's own Expositio consiliorum suorum, no longer extant. The credibility or otherwise of this controversial work must be dismissed from any enquiry into the identity of the mysterious figure, however. Asconius, in naming the two alternative possibilities, discloses himself to be without authoritative evidence on the point. Nothing can have been said in De consiliis suis to identify the house, the meeting, or the notorious nobleman. Asconius' words reveal that his attempt at an identification is based on Cicero's assertion therein of an overt hostility to him on the part of both Crassus and Caesar during the campaign. His attribution of a covert ‘dirty tricks’ operation to one of them is no more than speculation. (shrink)